Reflux appears to be a normal consequence of pregnancy which resolves postpartum. Often, symptoms are particularly prevalent postprandially and at night. Symptoms often begin in the latter part of the first trimester and persist into the second and then become more frequent and more severe in the third trimester. Although the prevalence of GER increases with advancing gestation time, a recent study has shown that the incidence of frequent GER (women starting with new symptoms) is consistent across the three trimesters (about 25% per trimester). The symptoms of gastro-oesophageal reflux (GER), heartburn and regurgitation, are common in pregnancy with 40–80% suffering at some time during the pregnancy, and these symptoms can have a marked impact upon quality of life. This prospective open-label study in a large number of pregnant women has shown that LG is both safe and highly efficacious in the treatment of heartburn and GER symptoms in pregnancy. Very few adverse events or serious adverse events were reported that were considered to be related to the study medication, and these were consistent with the normal population incidences. Treatment was deemed to be a success in 91% of patients as judged by the investigator (95% CI 85.0–95.3) and 90% (95% CI 84.1–94.8) when assessed by the patient themselves. The efficacy of the study medication was rated by the investigator (primary endpoint) and patient. The study was a multicentre, prospective, open-label, and baseline-controlled study of Liquid Gaviscon (LG) in the treatment of heartburn in pregnant women with current symptoms of heartburn and/or reflux requiring treatment (recruited 144). Here, we present a prospective clinical evaluation of the safety and efficacy of an alginate raft-forming oral suspension that is licensed for use in pregnancy. These symptoms are transient and mostly resolve postpartum but have a negative impact on quality of life. Gastro-oesophageal reflux (GER) and the symptoms of heartburn and regurgitation are common in pregnancy.
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